BMN-673: PARP Inhibitor for Genetically Defined Cancers
Poly ADP-ribose polymerase, or PARP, plays a key role in DNA repair by detecting
and initiating repair if a DNA strand breaks. PARP inhibitors inhibit DNA repair
in cancer cells, so cells deficient in other DNA repair pathways, such as those
seen with BRCA mutations, can be sensitive to PARP inhibitors eventually leading
to cell death.
BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development.